![]() ![]() Guidelines recommend a fasting lipid sample, 9 the benefits of evaluating risk with a non-fasting test in patients 7 When alcoholĬonsumption is accompanied by a meal containing fat it has a significant additive effect on the resultant triglycerideĪ non-fasting lipid test is acceptable for most patients requiring a CVD risk assessment. May cause an increase in triglyceride levels immediately following intake and after fasting. Per day for females, has very little acute effect on triglyceride levels. one to three standard drinks per day for males or one to two standard drinks Main meal, which contains balanced proportions of carbohydrates, protein and fat.Īlcohol can affect both fasting and non-fasting lipid tests * A “standard meal” is not precisely defined in the literature but can be Non-fasting triglyceride levels, four hours after a meal, are reported to be a strong predictor of cardiovascular eventsĪnd insulin resistance, and risk equations may be developed based on these levels in the future. Measuring non-fasting triglyceride levels may provide additional information for determining cardiovascular risk. 1, 3 If a patient has consumedĪ very high fat content meal prior to testing, or if they have slow lipid particle clearance after food (post-prandialĭyslipidaemia), triglyceride levels could be increased more than the estimated 0.3 mmol/L variance, and misrepresent clinical Triglyceride levels are increased for six to eight hours after a standard meal. * 3 Aĭecrease in lipid levels after a meal is perhaps converse to what would be expected, but this occurs due to the dilutionary 6įood intake has a minimal effect on lipid levelsĪ decrease in total cholesterol, HDL and LDL is observed for up to four hours after a standard meal. The differences are well within average biological variation between patients for each parameter. 3 These variations in lipid parametersĪre derived from average values in large population studies and deviations may be greater in individual patients. Mmol/L, the clinical significance of this variation will often be negligible. Overall, given that clinically important reductions in total and LDL cholesterol are considered to be greater than 1 Less than 20% for triglycerides (approximately 0.3 mmol/L increase for non-fasting vs fasting).Less than 10% for calculated low-density lipoprotein (LDL) cholesterol (approximately 0.2 mmol/L decrease for non-fasting.Less than 2% for high-density lipoprotein (HDL) cholesterol (approximately 0.1 mmol/L decrease for non-fasting vs.Less than 2% for total cholesterol (approximately 0.2 mmol/L decrease for non-fasting vs fasting).Mean lipid levels varied between fasting and non-fasting samples by: 1, 3, 5 5 Large-scale studies have indicated that There is little difference between fasting and non-fasting resultsįasting does not greatly alter the levels of lipid parameters. In addition,Ī fasting sample does not reflect the true biological state in which people spend the majority of their time. Results and place strain on testing facilities as a large influx of patients present for testing each morning. 1įasting requirements, however, are difficult for some patients and can reduce adherence with testing requests, delay It is alsoīecause the majority of research has been performed using fasting lipids, therefore it was assumed that making comparisonsĪnd analysing risk would be less precise if using non-fasting tests. This recommendation is based on achievingĬonsistency between patients and over multiple tests by ensuring a relatively standardised metabolic state. Monitoring response to statin treatmentĪt present, the majority of guidelines recommend a fasting serum lipid test.However, a growing body of evidence and international expert opinion suggests that a non-fasting lipid Fasting for at least eight hours prior to a lipid test has been standard practice in New Zealand and internationallyįor many years. ![]()
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